Waranya BoonchaiSupenya VarothaiWaranaree WinayanuwattikunSutasinee PhaitoonvatanakijPichanee ChaweekulratPranee KasemsarnFaculty of Medicine, Siriraj Hospital, Mahidol University2019-08-232019-08-232018-12-01Journal of Cosmetic Dermatology. Vol.17, No.6 (2018), 1130-113514732165147321302-s2.0-85041584389https://repository.li.mahidol.ac.th/handle/20.500.14594/46145© 2018 Wiley Periodicals, Inc. Background: Facial dermatitis can result from various conditions, some of which are of a chronic and relapsing nature. The use of topical corticosteroid therapy may lead to additional adverse effects. Objective: To compare the efficacy of moisturizer containing 4-t-butylcyclohexanol, which acts as a sensitivity regulator, and licochalcone A, an anti-inflammatory agent from the licorice plant Glycyrrhiza inflata, with that of 0.02% triamcinolone acetonide (TA) for the treatment of facial dermatitis. Methods: This was a randomized, prospective, investigator-blinded study. Eighty participants with mild to moderate facial dermatitis were randomly treated with either the test facial moisturizer or 0.02% TA twice daily for the first 2 weeks. For the subsequent 2 weeks, all patients used only the test moisturizer. Clinical assessment by investigators, bioengineering measurements, patients' subjective evaluation, and clinical photography were performed at baseline, week 2, and week 4. Results: Both treatments showed a statistically significant improvement with regard to physician clinical assessment, skin hydration, transepidermal water loss, and patient-assessed visual analog scale after 2 and 4 weeks of treatment compared with baseline. The test facial moisturizer produced better skin hydration than TCS. The improvement in TEWL after 4 weeks of using the test moisturizer was comparable with 2-week treatment with 0.02% TA cream. However, subjective evaluation by patients indicated that TA more rapidly improved sensation sensitivity. Conclusion: The test facial moisturizer was slower than 0.02% TA in improving facial dermatitis, but showed greater benefit in erythema control and skin hydration.Mahidol UniversityMedicineArticleSCOPUS10.1111/jocd.12499