Korporn SmitayothinKadkao VongsavanPraphasri RirattanapongPetcharat KraivaphanNoppakun VongsavanBruce MatthewsMahidol UniversityUniversity of Bristol2018-11-232018-11-232015-08-01Archives of Oral Biology. Vol.60, No.8 (2015), 1104-110818791506000399692-s2.0-84929312076https://repository.li.mahidol.ac.th/handle/20.500.14594/35413© 2015 Elsevier Ltd. All rights reserved. Abstract Objective To determine the effectiveness of the iontophoretic delivery of lignocaine with epinephrine through carious dentine for pain control during cavity preparation. Design The experiments were carried out on 56 carious molars that required class I restorations in 42 subjects (aged 15-20 years). The overhanging enamel and soft caries were removed then the sensitivity of the exposed dentine was tested with drilling, probing and air blast stimuli. The subject indicated the intensity of any pain produced by marking a visual analogue scale (VAS). The cavity was then filled with 20% w/v lidocaine with 0.1% w/v epinephrine and a 200 μA iontophoretic current applied for 2 min after which the sensitivity of the dentine was re-tested. If the dentine was not anaesthetized, the treatment and testing were repeated up to 6 times. Results The total duration (min) of iontophoresis required to anaesthetize the dentine was: 2 in 7 teeth, 4 in 17 teeth, 6 in 14 teeth, 8 in 4 teeth, and 10 in 7 teeth. The remaining 7 teeth were not anaesthetized even after 14 min of iontophoresis. Conclusions The iontophoretic delivery of lignocaine with epinephrine anaesthetized dentine for cavity preparation in 49 of 56 (87.5%) of carious molars.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyDentistryMedicineArticleSCOPUS10.1016/j.archoralbio.2015.04.005