Theerapong KrajaejunOnrapak ReamtongTassanee LohnooWanta YingyongRatchainant ThammasudjaritFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityMahidol University2020-01-272020-01-272019-10-01Medical mycology. Vol.57, No.7 (2019), 918-921146027092-s2.0-85072148493https://repository.li.mahidol.ac.th/handle/20.500.14594/51377© The Author(s) 2019. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. Pythium insidiosum causes the life-threatening disease, called pythiosis. Information on microbial pathogenesis could lead to an effective method of infection control. This study aims at assessing temperature-dependent proteomes, and identifying putative virulence factors of P. insidiosum. Protein extracts from growths at 25°C and 37°C were analyzed by mass spectrometry and SWISS-PROT database. A total of 1052 proteins were identified. Upon exposure to increased temperature, 219 proteins were markedly expressed, eight of which were putative virulence factors of P. insidiosum. These temperature-dependent proteins should be further investigated for their roles in pathogenesis, and some of which could be potential therapeutic targets.Mahidol UniversityMedicineArticleSCOPUS10.1093/mmy/myy164