Sommapun JueakaewRattana PiancharoensinNatchayakorn PinkesornSarunya ThippayaromNuttawut SermsathanasawadiFaculty of Medicine, Siriraj Hospital, Mahidol University2020-01-272020-01-272019-07-01Phlebology. Vol.34, No.6 (2019), 399-40514333031026835552-s2.0-85059354385https://repository.li.mahidol.ac.th/handle/20.500.14594/51553© The Author(s) 2018. Objective: To investigate the efficacy of a novel low-molecular-weight heparin injection technique compared to the standard technique relative to bruising incidence, bruise size, and pain. Methods: A randomized controlled trial was conducted in 44 patients with acute deep vein thrombosis. Patients who were randomized into the control group received a 10-s duration injection with immediate needle withdrawal, whereas study group patients received a 30-s duration injection with a 10-s pause before needle withdrawal. Two injection sites were assessed for pain and bruising between 48 and 60 h after injection. Results: Bruises occurred in 50.0% and 18.2% of control and study group patients, respectively (p = 0.03). Mean bruise size between 48 and 60 h after injection was 172.73 ± 372.60 mm2 and 28.18 ± 70.01 mm2 in the control group and study group, respectively (p = 0.026). Pain scores were comparable between groups. Conclusion: A 30-s duration injection with a 10-s pause before needle withdrawal resulted in significantly fewer and smaller bruises.Mahidol UniversityMedicineArticleSCOPUS10.1177/0268355518813512