Chain-length-dependent reactivity of alkenyl phosphates in ruthenium-catalyzed cross-metathesis

Pontavatchai A.Schwedtmann K.Royla P.Schwedtmann K.Khamnaen T.Schwarzenbolz U.Henle T.Somsook E.Weigand J.J.Mahidol University2025-12-112025-12-112025-01-01Chemical Communications (2025)13597345https://repository.li.mahidol.ac.th/handle/123456789/113457We report a chain-length-dependent reactivity pattern in the cross-metathesis of alkenyl phosphates catalyzed by the second-generation Grubbs catalyst (GII). While vinyl phosphates undergo unproductive decomposition to generate a ruthenium-carbide complex, extending the alkyl spacer restores productive cross-metathesis. DFT studies rationalize this transformation to occur via a proton-coupled phosphate elimination mechanism.Materials ScienceChemical EngineeringChemistryChain-length-dependent reactivity of alkenyl phosphates in ruthenium-catalyzed cross-metathesisArticleSCOPUS10.1039/d5cc05790f2-s2.0-1050235558721364548X