Amod SharmaMahidol University. Siriraj Hospital. Department of Physiology2017-08-042017-08-042017-08-042015Journal of Biomedical Science. Vol. 22, (2015), 93https://repository.li.mahidol.ac.th/handle/20.500.14594/2667Animal studies suggest that chronic monosodium glutamate (MSG) intake induces kidney damage by oxidative stress. However, the underlying mechanisms are still unclear, despite the growing evidence and consensus that α-ketoglutarate dehydrogenase, glutamate receptors and cystine-glutamate antiporter play an important role in up-regulation of oxidative stress in MSG-induced renal toxicity. This review summaries evidence from studies into MSG-induced renal oxidative damage, possible mechanisms and their importance from a toxicological viewpoint.engMahidol UniversityOpen Access articleMonosodium glutamateKidneyOxidative stressGlutamate receptorsα-Ketoglutarate dehydrogenaseReview ArticleBioMed Central10.1186/s12929-015-0192-5