Kripitch SutummapornKazuhiko SuzukiNoboru MachidaTetsuya MizutaniEun Sil ParkShigeru MorikawaTetsuya FuruyaNational Institute of Infectious DiseasesOkayama University of ScienceGifu UniversityMahidol UniversityTokyo University of Agriculture and Technology2020-10-052020-10-052020-01-01Archives of Virology. (2020)14328798030486082-s2.0-85089828227https://repository.li.mahidol.ac.th/handle/20.500.14594/59132© 2020, Springer-Verlag GmbH Austria, part of Springer Nature. In order to study potential pathogenic mechanisms of feline morbillivirus (FeMV) in infected kidney cells, we performed a terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and an immunofluorescence assay (IFA) with an anti-FeMV P protein antibody on a total of 38 cat kidney tissues, 12 of which were positive for FeMV. Among these samples, we detected significantly larger numbers of apoptotic cells in FeMV-positive tissues than in FeMV-negative tissues, and in these tissues, a substantial percentage of TUNEL-positive (TUNEL+) cells contained the FeMV P protein (mean, 37.4; range, 17.4-82.9), suggesting that induction of apoptosis may be an important mechanism for pathological changes associated with FeMV infection in cat kidney tissues.Mahidol UniversityImmunology and MicrobiologyArticleSCOPUS10.1007/s00705-020-04782-5