A new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata

S. BoonphongP. KittakoopM. IsakaP. PalittapongarnpimA. JaturapatK. DanwisetkanjanaM. TanticharoenY. ThebtaranonthNaresuan UniversityThailand National Center for Genetic Engineering and BiotechnologyMahidol University2018-09-072018-09-072001-04-26Planta Medica. Vol.67, No.3 (2001), 279-281003209432-s2.0-0035053787https://repository.li.mahidol.ac.th/handle/123456789/26465Bioassay-guided fractionation of the cell extract of the insect pathogenic fungus Aschersonia tubulata BCC 1785 led to the isolation of dustanin (1), 3β,15α,22-trihydroxyhopane (3), 5α,8α-epidioxy-24(R)-methylcholesta-6,22-diene-3β-ol (6), together with the new 3β-acetoxy-15α,22-dihydroxyhopane (4). Chemical structures of these compounds were elucidated by spectral analyses as well as chemical transformation. Compounds I and 4 exhibited antimycobacterial activity with the minimum inhibitory concentration (MIC) of 12:5 μg/ml.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsA new antimycobacterial, 3β-acetoxy-15α,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulataArticleSCOPUS10.1055/s-2001-11997