L. WalshM. D. SmithV. WuthiekanunN. J. WhiteMahidol University2018-07-042018-07-041995-01-01Antimicrobial Agents and Chemotherapy. Vol.39, No.10 (1995), 2356-2358006648042-s2.0-0029147063https://repository.li.mahidol.ac.th/handle/123456789/17452The postantibiotic effects (PAEs) of 16 antibiotics or antibiotic combinations currently used against Burkholderia (Pseudomonas) pseudomallei were determined. The β-lactams had zero PAEs, while the carbapenems and ciprofloxacin induced median PAEs of 1 and 5 h, respectively. These results emphasize the need to maintain antibiotic levels above inhibitory concentrations in blood throughout the dosing interval in cases of severe melioidosis.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1128/AAC.39.10.2356