N. J. WhiteS. LooareesuwanK. SilamutMahidol University2018-10-122018-10-121983-01-01American Journal of Tropical Medicine and Hygiene. Vol.32, No.3 (1983), 456-460000296372-s2.0-0020580843https://repository.li.mahidol.ac.th/handle/20.500.14594/30474Red cell concentrations of quinine were measured in cerebral malaria and in uncomplicated falciparum malaria both in the acute stage and 1 month after recovery. Red cell quinine elimination half times were significantly shorter than the corresponding plasma half time in cerebral malaria and convalescent uncomplicated cases (P <0.001), but not in acute uncomplicated cases (P = 0.12). The ratio of red cell:plasma concentration fell progressively from the 2nd (0.49) to the 6th day (0.26) of treatment. On admission this ratio was positively correlated with the blood parasite count (P = 0.02). Red cell quinine concentration may be relevant to the assessment of drug resistance, and to the design of treatment regimens.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.4269/ajtmh.1983.32.456