Chawan ManasponPinunta NittayacharnKetpat VejjasilpaChayut FongsukNorased NasongklaMahidol University2018-05-032018-05-032011-12-26Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. (2011), 3241-32441557170X2-s2.0-84055176546https://repository.li.mahidol.ac.th/handle/20.500.14594/11739One of the most useful techniques to treat cancer is chemotherapy. However, anticancer drugs, such as SN-38, have limited solubility with strong side effects. This work aims to use SN-38:-cyclodextrin (β-CD) inclusion complex for an injectable polymeric in situ forming implant containing poly(ethylene glycol) (PEG), poly(β-caprolactone), and poly(D, L-lactide). It was found that implant formation and SN-38 encapsulation efficiency directly depended on weight ratio of SN-38 and β-CD. At the ratio of SN-38:β-CD of 1:7, the implant could not be formed perfectly and had lower encapsulation efficiency. Reduction of the amount of β-CD to the ratio of 1:3 showed the higher encapsulation efficiency at 89.7 %. SN-38 release rate was also found to depend on β-CD content and the implant weight. In addition, their active form was protected when encapsulated inside implants. © 2011 IEEE.Mahidol UniversityComputer ScienceEngineeringMedicineConference PaperSCOPUS10.1109/IEMBS.2011.6090881