Ampaiwan ChuansumritNongnuch SirachainanRungrote NatesirinilkulKwannut SrikalaNarongrit Masaya-anonAjchariya SarovathAtthaporn BoongirdBunchoo PongtanakulChalermpong ChatdokmaipraiChane Cheod-amphaiChusak KijkunasathianJakrapan JirasirithamJariya Pree-siriJumroon TungkeeratichaiMonratta PanuwannakornNantana Sri-UdompornNatsaruth SongthaweePantep AngchaisuksiriPakawan WongwerawattanakoonPraguywan KadegasemPimlak CharoenkwanPimpun KitpokaSiranee WongruangsriSuphaneewan JaovisidhaSurapong LertthammakiatTanit VirankabutraWerasak SasanakulYujinda LektrakulSiriraj HospitalLampang HospitalFaculty of Medicine Ramathibodi Hospital, Mahidol UniversityPrince of Songkla UniversityNan HospitalChiang Mai UniversitySunprasitthiprasong Hospital2022-08-042022-08-042021-01-01Haemophilia. Vol.27, No.1 (2021), 69-8013652516135182162-s2.0-85102090684https://repository.li.mahidol.ac.th/handle/123456789/78806Objective: This study aimed to explore real-world evidence on health resource use (HRU) spending on patients with haemophilia and inhibitor. Materials and methods: Medical records from 1990 to 2019 of patients with haemophilia and inhibitor from three comprehensive haemophilia treatment centres were retrospectively retrieved. Results: In all, 31 patients with haemophilia (A = 30, B = 1) and inhibitor ≥5 BU were included. The mean initial inhibitor of 95.4 BU was detected at the mean age of 6.7 years. The mean number of annual hospitalisations was 3.9. A total of 795 bleeding episodes (major =125, minor =670) were evaluated. The treatment included bypassing agents or plasma exchange before administering high-dose factor VIII concentrate and intervention or surgery. Six patients succumbed to bleeding at the mean age of 17.2 years. Nineteen surviving patients experienced multiple morbidity except six patients with successful and partially successful immune tolerance induction (ITI). The mean (SD) annual total medical consumption for episodic treatment and successful ITI per patient with haemophilia A were 30,804 (81,332) USD and 55,531 (100,566) USD, respectively. Only episodic treatment was paid by the government budget for limited amounts of bypassing agents. Conclusion: Management for patients with haemophilia and inhibitor exhibiting severe bleeding is challenging for medical personnel in countries having limited resources over decades. The real-world data will be used to negotiate with the government to increase budget for adequate bypassing agents or nonreplacement therapy and to include ITI in the national haemophilia treatment.Mahidol UniversityMedicineArticleSCOPUS10.1111/hae.14194