Jean DarcourtPattarawit WithayasukIvan VukasinovicCaterina MichelozziGuillaume BellangerAdrien GuenegoGilles AdamMargaux RoquesAnne Christine JanuelPhilippe TallOlivier MeyrignacVanessa RousseauCédric GarciaJean François AlbucherBernard PayrastreFabrice BonnevilleJean Marc OlivotChristophe CognardUniversite Paul Sabatier Toulouse IIICHU de ToulouseMahidol UniversityUniversity Hospital Clinical Center of2020-01-272020-01-272019-02-01Stroke. Vol.50, No.2 (2019), 512-515152446282-s2.0-85060617338https://repository.li.mahidol.ac.th/handle/123456789/51921Background and Purpose- Our goal was to evaluate whether the presence of a low signal intensity known as susceptibility vessel sign (SVS) on T2*-gradient echo imaging sequence was predictive of arterial recanalization and the early clinical improvement after mechanical thrombectomy. Methods- This observational study was based on a prospective database of acute ischemic strokes treated by mechanical thrombectomy. Inclusion criteria were patients with acute anterior ischemic stroke, diagnosed by magnetic resonance imaging, including a T2*-gradient echo imaging sequence, and treated by mechanical thrombectomy. Two independent readers assessed the presence of an SVS. Successful recanalization was defined as a Thrombolysis in Cerebral Infarction score of 2b-3 after mechanical thrombectomy. Early clinical improvement was estimated by the difference between the baseline National Institutes of Health Stroke Scale and the National Institutes of Health Stroke Scale on day 1 after treatment Results- The SVS was detected in 137 (76%) out of 180 patients. The kappa interrater agreement was 0.71 with a 95% CI of 0.59 to 0.82. Successful recanalization was associated with an SVS+ with odds ratio, 2.48; 95% CI, 1.05-5.74; P=0.03. The early clinical improvement was better in patients with an SVS+ (median, -6; interquartile range, -11 to 0) compared with SVS- patients (median, -1; interquartile range, -10 to 3) with P=0.01. Conclusions- The visualization of SVS is a reliable and easily accessible predictive factor of recanalization success and early clinical improvement.Mahidol UniversityMedicineArticleSCOPUS10.1161/STROKEAHA.118.022912