Ittikorn SpanuchartBakhtiar AminAdrian SequeiraChiranjiv VirkKenneth AbreoBharat SachdevaFaculty of Medicine Ramathibodi Hospital, Mahidol UniversityLSU Health Sciences Center - Shreveport2022-08-042022-08-042021-01-01Journal of Vascular Access. (2021)112972982-s2.0-85105707684https://repository.li.mahidol.ac.th/handle/123456789/78745Arteriovenous fistula (AVF) thrombosis occurs less often when compared to arteriovenous grafts. Since the number of AVFs has increased in the United States, AVF thrombosis is seen more frequently today. AVF thrombectomy can be tedious, requires physician ingenuity, and many times results in failure. Substantial clot burden in megafistulas and aneurysms is considered a relative contraindication to endovascular thrombectomy. Usually, it results in surgical referral for open thrombectomy or, at times, abandonment of the fistula altogether. Herein, we describe the technique, results, and cautions of combining a continuous infusion of recombinant tissue plasminogen (rTPA) followed by angioplasty of the culprit stenotic lesion that was successful in opening five of six AVFs with a substantial clot burden.Mahidol UniversityMedicineArticleSCOPUS10.1177/11297298211011916