Helen E. FosterChristiaan ScottCarl J. TideriusMatthew B. DobbsElizabeth AngSirirat CharuvanijWendy CostelloMarja KinnunenLaura B. LewandowskiAngela MigowaSimon R. StonesSoamarat VilaiyukKate WebbSchool of Medical EducationAga Khan Hospital NairobiSt. Louis Children's HospitalYong Loo Lin School of MedicineFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversitySkånes universitetssjukhusRed Cross War Memorial Children's HospitalFaculty of Medicine, Siriraj Hospital, Mahidol UniversityUniversity of Cape TownEuropean Network for Children with Arthritis and Autoinflammatory DiseasesCollaboro ConsultingNational Institutes of of Arthritis and Musculoskeletal and Skin DiseasesFinnish Nurses Association2020-08-252020-08-252020-01-01Best Practice and Research: Clinical Rheumatology. (2020)15321770152169422-s2.0-85088433853https://repository.li.mahidol.ac.th/handle/20.500.14594/58340© 2020 Elsevier Ltd This chapter describes the musculoskeletal (MSK) context in children and young people as an important contributor to the global non-communicable disease burden. Through selected MSK conditions, we describe the impact on patients, families and communities and highlight the challenges that need to be addressed. We focus on opportunities for better working together and describe exemplar initiatives to raise awareness, workforce capacity building, models of care and research agendas to have a greater global context.Mahidol UniversityMedicineReviewSCOPUS10.1016/j.berh.2020.101566