Manat PohmakotrNattawut YotapanPatoomratana TuchindaChutima KuhakarnVichai ReutrakulMahidol University2018-08-242018-08-242007-06-22Journal of Organic Chemistry. Vol.72, No.13 (2007), 5016-5019002232632-s2.0-34250885710https://repository.li.mahidol.ac.th/handle/20.500.14594/24348(Chemical Equation Presented) Functionalized γ-lactams are found to be crucial intermediates in the synthesis of biologically important natural products. We herein described a highly diastereoselective synthesis of β-carboxy-γ-lactams and their ethyl ester derivatives, in high yields with high diastereomeric ratio, via the Mukaiyama-aldol type reaction of 2,5-bis(trimethysilyloxy)furan with imines, employing Sc(OTf)3 as a catalyst. © 2007 American Chemical Society.Mahidol UniversityChemistryArticleSCOPUS10.1021/jo070533r