Daniel N. HupaloZunping LuoAlexandre MelnikovPatrick L. SuttonPeter RogovAnanias EscalanteAndrés F. VallejoSócrates HerreraMyriam Arévalo-HerreraQi FanYing WangLiwang CuiCarmen M. LucasSalomon DurandJuan F. SanchezG. Christian BaldevianoAndres G. LescanoMoses LamanCeline BarnadasAlyssa BarryIvo MuellerJames W. KazuraAlex EapenDeena KanagarajNeena ValechaMarcelo U. FerreiraWanlapa RoobsoongWang NguitragoolJetsumon SattabonkotDionicia GamboaMargaret KosekJoseph M. VinetzLilia González-CerónBruce W. BirrenDaniel E. NeafseyJane M. CarltonNew York UniversityBroad InstituteTemple UniversityCaucaseco Scientific Research CenterUniversidad del Valle, CaliDalian Institute of BiotechnologyThird Military Medical UniversityPennsylvania State UniversityUS Naval Medical Research Unit No. 6Papua New Guinea Institute of Medical ResearchWalter and Eliza Hall Institute of Medical ResearchUniversity of MelbourneInstituto de Salud Global de BarcelonaCase Western Reserve UniversityNational Institute of Malaria Research IndiaUniversidade de Sao Paulo - USPMahidol UniversityUniversidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von HumboldtUniversidad Peruana Cayetano HerediaJohns Hopkins Bloomberg School of Public HealthUniversity of California, San DiegoNational Institute for Public Health2018-12-112019-03-142018-12-112019-03-142016-08-01Nature Genetics. Vol.48, No.8 (2016), 953-95815461718106140362-s2.0-84976273742https://repository.li.mahidol.ac.th/handle/123456789/42970© 2016 Nature America, Inc. All rights reserved. Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P. vivax genome by sequencing 182 clinical isolates sampled from 11 countries across the globe, using hybrid selection to overcome human DNA contamination. We confirmed previous reports of high genomic diversity in P. vivax relative to the more virulent Plasmodium falciparum species; regional populations of P. vivax exhibited greater diversity than the global P. falciparum population, indicating a large and/or stable population. Signals of natural selection suggest that P. vivax is evolving in response to antimalarial drugs and is adapting to regional differences in the human host and the mosquito vector. These findings underline the variable epidemiology of this parasite species and highlight the breadth of approaches that may be required to eliminate P. vivax globally.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1038/ng.3588