Ratchanok PingaewSomsak RuchirawatMahidol UniversityChulabhorn Research InstituteThe Institute of Science and Technology for Research and Development, Mahidol University2018-08-242018-08-242007-09-17Synlett. No.15 (2007), 2363-2366093652142-s2.0-34948839846https://repository.li.mahidol.ac.th/handle/123456789/24337The oxidative biaryl coupling of various N-substituted 1- benzyltetrahydroisoquinolines to the corresponding aporphines by the hypervalent iodine reagent was studied. The study sheds light on the unifying mechanism of the reaction illustrating the requirement of the p-p coupling via the six-membered transition state as the initial step. The finding was applied to the synthesis of some pentasubstituted aporphine alkaloids. © Georg Thieme Verlag Stuttgart.Mahidol UniversityChemistryArticleSCOPUS10.1055/s-2007-985596