Danai TiwawechMasao HiroseMitsuru FutakuchiCui LinWitaya ThamavitNobuyuki ItoTomoyuki ShiraiNational Cancer Institute ThailandNagoya City University Medical SchoolMahidol University2018-09-072018-09-072000-10-01Cancer Letters. Vol.158, No.2 (2000), 195-201030438352-s2.0-0034308146https://repository.li.mahidol.ac.th/handle/20.500.14594/25855Boesenbergia pandurata (Zingiberaceae), Languas galanga (Zingiberaceae) and Citrus hystrix (Rutaceae) are edible plants that are commonly used as flavors or condiments in various Thai food dishes. They are known to exert strong anti-promoting activity in a test of tumor promoter-induced Epstein- Barr virus (EBV) activation. In the present study their effects on hepatocarcinogenesis were investigated in a medium-term bioassay using F344 male rats. C. hystrix significantly enhanced 2-amino-3,8-dimethylimidazo(4,5- f)quinoxaline-associated preneoplastic liver cell focus development while B. pandurata and L. galanga had borderline effects. The results suggest that C. hystrix as well as B. pandurata and L. galanga may contain agents augmenting the hepatocarcinogenicity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline. (C) 2000 Elsevier Science Ireland Ltd.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1016/S0304-3835(00)00530-9