Sarunya PhunpeeKunat SukthamSuvimol SurassmoSuwatchai JarussophonChompoonut RungnimApinan SoottitantawatSatit PuttipipatkhachornUracha Rungsardthong RuktanonchaiChulalongkorn UniversityMahidol UniversityThailand National Science and Technology Development Agency2019-08-282019-08-282018-03-01International Journal of Pharmaceutics. Vol.538, No.1-2 (2018), 21-2918733476037851732-s2.0-85040354898https://repository.li.mahidol.ac.th/handle/20.500.14594/47324© 2017 Elsevier B.V. In this study, the inclusion complex formation between α-mangostin and water-soluble quaternized β-CD grafted-chitosan (QCD-g-CS) was investigated. Inclusion complex formation with encapsulation efficiency (%EE) of 5, 15 and 75% can be varied using high speed homogenizer. Tuning %EE plays a role on physicochemical and biological properties of α-mangostin/QCD-g-CS complex. Molecular dynamics simulations indicate that α-mangostin is included within the hydrophobic β-CD cavity and being absorbed on the QCD-g-CS surface, with these results being confirmed by Fourier transform infrared (FTIR) spectroscopy. Probing the release characteristics of the inclusion complex at various %EE (5%, 15% and 75%) in simulated saliva (pH 6.8) demonstrated that α-mangostin release rates were dependent on % EE (order 5% > 15% > 75%). Additionally, higher antimicrobial and anti-inflammation activities were observed for the inclusion complex than those of free α-mangostin due to enhance the solubility of α-mangostin through the inclusion complex with QCD-g-CS.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.ijpharm.2017.12.016