Thongperm MunkongdeeDalad PichanunPunnee ButthepSumonmaln KlamchuenVeeradet ChalermpolprapaPranee WinichagoonSaovaros SvastiSuthat FucharoenMahidol UniversityNakornpathom Hospital2018-05-032018-05-032011-07-01Annals of Hematology. Vol.90, No.7 (2011), 741-74614320584093955552-s2.0-79960282616https://repository.li.mahidol.ac.th/handle/20.500.14594/12439It has long been recognized that the presence of hemoglobin (Hb) Bart's in newborn's blood is associated with α-thalassemia. However, the automated high-performance liquid chromatography or low-performance liquid chromatography system is unable to quantify the amount of Hbs Bart's and H, which are eluted at the retention time close to 0 min. This study used automatic capillary electrophoresis (CE) system to diagnose various types of α-thalassemia in 587 cord blood samples, including 429 normal α-globin genotype, 120 cases of thalassemia with one α-globin gene defect, 34 cases with two α-globin genes defect, and four cases with three α-globin genes defect. The result showed that the level of Hb Bart's in cord blood was increased accordingly with the increasing numbers of the defective α-globin genes. In addition, Hb Bart's level at 0.2%, as measured by CE, can be used as a cut-off point for α-thalassemia diagnosis in newborns. © 2010 Springer-Verlag.Mahidol UniversityMedicineArticleSCOPUS10.1007/s00277-010-1137-4