Onnicha KhaikateNatthamon InthalaengJatuporn MeesinKritchasorn KantarodManat PohmakotrVichai ReutrakulDarunee SoorukramPawaret LeowanawatChutima KuhakarnMahidol University2020-01-272020-01-272019-01-01Journal of Organic Chemistry. (2019)15206904002232632-s2.0-85075579753https://repository.li.mahidol.ac.th/handle/123456789/50581© 2019 American Chemical Society. A new synthetic approach for the synthesis of indolo[2,3-b]quinolines and benzothieno[2,3-b]quinolines has been developed by employing the freshly prepared o-alkynylisocyanobenzenes derived from o-alkynylformamide derivatives as substrates. The synthetic transformations involved chloride-ion-triggered 6-endo cyclization of o-alkynylisocyanobenzenes to generate 2-chloroquinolines in situ, which further cyclized intramolecularly with nitrogen or sulfur atom via a cascade process to provide the corresponding indolo[2,3-b]quinolines and benzothieno[2,3-b]quinolines, respectively, in moderate to excellent yields.Mahidol UniversityChemistryArticleSCOPUS10.1021/acs.joc.9b02081