Sroisiri ThaweboonSiriruk NakornchaiYasuo MiyakeTakaaki YanagisawaBoonyanit ThaweboonSurin Soo-amponDuangjai LexomboonMahidol UniversityTokyo Dental College2018-09-132018-09-132009-03-01Southeast Asian Journal of Tropical Medicine and Public Health. Vol.40, No.2 (2009), 345-353012515622-s2.0-63149089375https://repository.li.mahidol.ac.th/handle/20.500.14594/28164The aim of the present study was to determine the remineralization effects of xylitol chewing gum containing funoran and calcium hydrogenphosphate on enamel subsurface lesions in humans. The study was a double-blind, randomized, cross-over design, with 4 types of gum: (1) xylitol gum, (2) xylitol gum containing funoran and calcium hydrogenphosphate, (3) sugar gum, and (4) gum base as a control. Seven subjects were instructed to wear removable lingual appliances, with half-slab insets of human enamel containing demineralized subsurface lesions. They were told to chew gum for 20 minutes 4 times per day for 7 days. Upon completion of each treatment the enamel half-slabs were paired with their respective demineralized control half-slabs, embedded, sectioned, and subjected to microradiography and densitometric image analysis, for measurement of the level of remineralization. The mean area of remineralization (ΔZd-ΔZr) and mean peicent remineralization (%R) in those chewing xylitol gum containing funoran and calcium hydrogenphosphate were significantly higher than the corresponding values for xylitol gum, sugar gum and gum base. Chewing xylitol gum containing funoran and calcium hydrogenphosphate has a significant effect on the remineralization of initial caries-like lesions of the teeth.Mahidol UniversityMedicineArticleSCOPUS