Anong Kitjaroenthamอนงค์ กิจเจริญธรรมHathairad Hananantachaiหทัยรัชต หาญอนันตชัยBenjaluck PhonratSangchai PreutthipanRungsunn Tungtrongchitrรังสรรค์ ตั้งตรงจิตรMahidol University. Faculty of Tropical Medicine. Department of Tropical Nutrition and Food ScienceMahidol University. Faculty of Tropical Medicine. Department of Social and Environmental MedicineMahidol University. Faculty of Tropical Medicine. Department of Clinical Medicine2015-07-092021-08-172015-07-092021-08-172015-07-092014https://repository.li.mahidol.ac.th/handle/123456789/63185Joint International Tropical Medicine Meeting 2014: 3D perspectives on tropical medicine: drivers, diversity and determination the 8th seminar on food-and water-borne parasitic zoonoses: 2-4 December 2014: Centara Grand Bangkok Convention Center at Central World, Bangkok, Thailand. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2014. p. 261.Postmenopausal osteoporosis and bone mass are influenced by multiple factors including genetics. Low density lipoprotein receptor related protein 5 (LRP5), a co-receptor of Wnt signaling, is an important regulator of bone development and maintenance. The presence of a LRP5 single nucleotide polymorphism (SNP), A1330V, was determined by PCR-RFLP method in 332 Thai menopausal women. AA genotype subjects had lower radial BMD (p value = 0.015). Furthermore, women with low BMI (≤ 25) had higher risk of radial BMD osteoporosis (Odd’s ratio = 7.41, p value = 0.007) but aging (50 years) and A1330V SNP had no effect. In conclusion, LRP5 A1330V SNP may contribute to osteoporosis susceptibility in Thai menopausal women.engMahidol UniversityA1330VBMDLRP5OsteoporosisPostmenopausal womenProceeding Poster