M. A. PfallerD. J. DiekemaM. G. RinaldiR. BarnesB. HuA. V. VeselovN. TiraboschiE. NagyD. L. GibbsJorge FinquelievichDavid EllisDominique FramereeAnnemarie Van Den AbeeleJean Marc SenterreArnaldo ColomboRobert RennieSteve SancheBijie HuYingchun XuYingyuan ZhangNan Shan ZhongPilar RivasAngela RestrepoCatalina BedoutRicardo Vega Matilde MendezNada MallatovaEva ChmelarovaJulio AyabacaJeannete ZuritaM. MallieE. CandolfiW. FegelerA. HaaseG. RodloffW. BarV. CzaikaGeorge PetrikosErzsébet PuskásIlona DocziMestyan GyulaRadka NikolovaUma BanerjeeNathan KellerVivian TullioGian Carlo SchitoGiacomo FortinaGian Piero TestoreDomenico D'AntonioGiorgio ScalisePietro MartinoGraziana MannoKee PengCelia AlpucheEduardo Rodriguez NoriegaMussaret ZaidiJacques F.G.M. MeisEgil LingaasDanuta DzierzanowskaWaclaw PawliszynMariada Luz MartinsLuis AlbuquerqueLaura RosadoRosa VelhoJose AmorimVera N. IlinaOlga I. KretchikovaGalina A. KlyasovaSophia M. RozanovaIrina G. MultykhNikolay N. KlimkoElena D. AgapovaNatalya V. DmitrievaAbdul Mohsen Al-RasheedJan TruplLeon LangsadlAlena VaculikovaHupkova HelenaDenise RoditiAnwar HoosenH. H. Crewe-BrownM. N. Janse Van RensburgAdriano DuseKyungwon LeeMi Na KimA. Del PalacioAurora Sanchez-SousaJacques BilleK. MuhlethalerShan Chwen ChangJen Hsien WangMalai VorachitDeniz GurVolkan KortenJohn PaulBrian JonesF. Kate GouldChris KibblerNigel WeightmanIan M. GouldRuth AshbeeUniversity of Iowa Carver College of MedicineUniversity of Texas Health Science Center at San AntonioUniversity of WalesZhongshan Hospital ShanghaiInstitute of Antimicrobial ChemotherapyHospital de Clinicas Jose de San MartinUniversity of Szeged Faculty of MedicineGiles Scientific, Inc.Universidad de Buenos AiresWomen's and Children's Hospital AdelaideCHU de JumetSt Lucas Campus Heilige FamilieCentre Hospitalier Regional de La CitadelleUniversidade Federal de Sao PauloUniversity of Alberta HospitalRoyal University HospitalUniversitario de CaracasPeking Union Medical CollegeHuashan HospitalGuangzhou Institute of Repiratory DiseaseInst. Nacional de CancerologýaCIBHospital Militar Central, BogotaHospital Ceske BudejoviceKrajska Hygienicka stanice se sidlem v OstraveHospital FF. AA HG1Hospital VozandesUniversite de MontpellierInstitut de ParasitologieWestfalische Wilhelms-Universitat MunsterRheinisch-Westfalische Technische Hochschule AachenInst. F. Med. MikrobiologieCarl-Thiem-KlinikumHumaine KlinikenLaikon General HospitalBAZ County InstituteSzegedi Tudomanyegyetem (SZTE)Pecsi TudomanyegyetemSzent Laszlo HospitalAll India Institute of Medical Sciences, New DelhiChaim Sheba Medical Center IsraelUniversita degli Studi di TorinoUniversita degli Studi di GenovaOspedale di NovaraUniversita degli Studi di Roma Tor VergataOspedale Civile di PescaraInstituto di Malattie InfettiveUniversity of MalayaHospital General de MexicoUniversidad de GuadalajaraHospital General O'HoranNijmegen Interdenominational Hospital Canisius-WilhelminaRikshospitalet-Radiumhospitalet HFInstytut Pomnik-Centrum Zdrowia DzieckaPracownia BakteriologiiUniversidade Nova de Lisboa, Instituto de Higiene e Medicina TropicalCentro Hospitalar e Universitario de CoimbraInstituto Nacional de Saude Dr. Ricardo JorgeHospital Geral de Santo AntonioNovosibirsk Regional HospitalGen del Este Domingo LucianiNational Research Center for HematologyCity Clinical Hospital No.Territory Center of Laboratory DiagnosticsMedical Mycology Research InstituteIrkutsk Regional Childrens HospitalOncology Research CenterRiyadh Military HospitalNational Cancer CenterNUTaRCHDerer's University Hospital SlovakiaSt. Cyril and Method's HospitalGroote Schuur HospitalGa-Rankuwa HospitalBaragwanath HospitalUniversity of the Free StateJohannesburg HospitalYonsei UniversityAsan Medical CenterHospital 12 De OctobreHospital Ramon y CajalCentre Hospitalier Universitaire VaudoisUniversitat BernNational Taiwan University HospitalChina Medical University Hospital TaichungMahidol UniversityHacettepe UniversitesiMarmara Universitesi Tip FakultesiRoyal Sussex County HospitalGlasgow Royal InfirmaryFreeman HospitalUCLFriarage HospitalAberdeen Royal InfirmaryLeeds General InfirmaryWayne State UniversityThe Mount Sinai Medical CenterWeill Cornell Medical CenterStanford University Medical CenterUniversity Hospitals Case Medical CenterUniversity of VirginiaChristiana Care2018-06-212018-06-212005-12-01Journal of Clinical Microbiology. Vol.43, No.12 (2005), 5848-5859009511372-s2.0-30744462355https://repository.li.mahidol.ac.th/handle/20.500.14594/16732© 2005, American Society for Microbiology. All Rights Reserved. Fluconazole in vitro susceptibility test results for 140,767 yeasts were collected from 127 participating investigators in 39 countries from June 1997 through December 2003. Data were collected on 79,343 yeast isolates tested with voriconazole from 2001 through 2003. All investigators tested clinical yeast isolates by the CLSI (formerly NCCLS) M44-A disk diffusion method. Test plates were automatically read and results were recorded with the BIOMIC Vision Image Analysis System. Species, drug, zone diameter, susceptibility category, and quality control results were collected quarterly via e-mail for analysis. Duplicate (the same patient, same species, and same susceptible-resistant biotype profile during any 7-day period) and uncontrolled test results were not analyzed. The 10 most common species of yeasts all showed less resistance to voriconazole than to fluconazole. Candida krusei showed the largest difference, with over 70% resistance to fluconazole and less than 8% to voriconazole. All species of yeasts tested were more susceptible to voriconazole than to fluconazole, assuming proposed interpretive breakpoints of ≥17 mm (susceptible) and ≤13 mm (resistant) for voriconazole. MICs reported in this study were determined from the zone diameter in millimeters from the continuous agar gradient around each disk, which was calibrated with MICs determined from the standard CLSI M27-A2 broth dilution method by balanced-weight regression analysis. The results from this investigation demonstrate the broad spectrum of the azoles for most of the opportunistic yeast pathogens but also highlight several areas where resistance may be progressing and/or where previously rare species may be "emerging".Mahidol UniversityMedicineArticleSCOPUS10.1128/JCM.43.12.5848-5859.2005