Onsod P.Jaranasaksakul W.Chareonsirisuthigul T.Parinayok R.Rerkamnuaychoke B.Areesirisuk P.Mahidol University2024-05-152024-05-152024-07-01European Journal of Obstetrics and Gynecology and Reproductive Biology Vol.298 (2024) , 31-3403012115https://repository.li.mahidol.ac.th/handle/20.500.14594/98342Objective: This study evaluated the BACs-on-Beads™ (BoBs) efficiency assay in detecting chromosomal anomalies in products of conception (POC) specimens associated with anembryonic pregnancy (AP) among Thai pregnant women. Method: Retrospective analysis applied the BoBs™ assay to examine AP samples from 2010 to 2022. The incidences of AP with chromosomal abnormalities were reported. Result: Assessment of villi from anembryonic pregnancy samples found normal chromosome complement in 50% of the cases, while the remainder showed chromosomal abnormalities. Trisomy 16 was found in 15% of the cases and trisomies 22, 15, and 19 in 9.6%, 3.8%, and 3.8%, respectively. Advanced maternal age was associated with a higher incidence of aneuploidy. Conclusion: The BoBs™ assay effectively detected diverse chromosomal abnormalities in villi samples from POC. The diagnostic utility of the BoBs™ assay was highlighted in identifying chromosomal irregularities in AP cases. Trisomy 16 possessed the most chromosomal abnormalities in the AP samples.MedicineArticleSCOPUS10.1016/j.ejogrb.2024.04.0412-s2.0-851923858721872765438705011