Chulabhorn MahidolHunsa PrawatWirongrong KaweetripobSomsak RuchirawatChulabhorn Research InstituteThe Institute of Science and Technology for Research and Development, Mahidol UniversityMahidol University2018-07-242018-07-242002-07-01Heterocycles. Vol.57, No.7 (2002), 1287-1292038554142-s2.0-0036645860https://repository.li.mahidol.ac.th/handle/20.500.14594/20125Two new flavonoids, 4′,5-dihydroxy-8-hydroxymethyl-6″,6″- dimethylpyrano[2′,3′:7,6]flavanone (1), and 2′,3′-dihydroxylupinifolin (2) were isolated from the stems of Derris reticulata. Both compounds showed cytotoxic activity in the P-388 cell line. The structures were established by spectroscopic analysis and chemical transformations. The biosynthetic origin and the mechanism of formation of the hydroxymethyl group in compound (1) are proposed.Mahidol UniversityChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS