Weeraphat Pon-OnNarattaphol CharoenphandhuJarinthorn TeerapornpuntakitJirawan ThongbunchooNateetip KrishnamraI. Ming TangKasetsart UniversityMahidol UniversityCommission of Higher Education2018-10-192018-10-192013-04-01Materials Science and Engineering C. Vol.33, No.3 (2013), 1423-1431092849312-s2.0-84873408093https://repository.li.mahidol.ac.th/handle/20.500.14594/31759A drug delivery vehicle consisting of spherical calcium phosphate-collagen particles covered by flower-like (SFCaPCol) blossoms composed of nanorod building blocks and their cellular response is studied. The spherical structure was achieved by a combination of sonication and freeze-drying. The SFCaPCol blossoms have a high surface area of approximately 280 m2g- 1. The blossom-like formation having a high surface area allows a drug loading efficiency of 77.82%. The release profile for one drug, vancomycin (VCM), shows long term sustained release in simulated body fluid (SBF), in a phosphate buffer saline (PBS, pH 7.4) solution and in culture media over 2 weeks with a cumulative release ∼ 53%, 75% and 50%, respectively, over the first 7 days. The biocompatibility of the VCM-loaded SFCaPCol scaffold was determined by in vitro cell adhesion and proliferation tests of rat osteoblast-like UMR-106 cells. MTT tests indicated that UMR-106 cells were viable after exposure to the VCM loaded SFCaPCol, meaning that the scaffold (the flower-like blossoms) did not impair the cell's viability. The density of cells on the substrate was seen to increase with increasing cultured time. © 2012 Elsevier B.V. All Rights Reserved.Mahidol UniversityEngineeringMaterials ScienceMedicinePhysics and AstronomyArticleSCOPUS10.1016/j.msec.2012.12.046