Chiea Chuen KhorTan DoHongyan JiaMasakazu NakanoRonnie GeorgeKhaled Abu-AmeroRoopam DuveshLi Jia ChenZheng LiMonisha E. NongpiurShamira A. PereraChunyan QiaoHon Tym WongHiroshi SakaiMônica Barbosa De MeloMei Chin LeeAnita SChanYaakub AzhanyThi Lam Huong DaoYoko IkedaRodolfo A. Perez-GrossmannTomasz ZarnowskiAlexander C. DayJost B. JonasPancy O.S. TamTuan Anh TranHumaira AyubFarah AkhtarShazia MichealPaul T.K. ChewLeyla A. AljasimTanuj DadaTam Thi LuuMona S. AwadallaNaris KitnarongBoonsong WanichwecharungruangYee Yee AungJelinar Mohamed-NoorSaravanan VijayanSripriya SarangapaniRahat HusainAliza JapMani BaskaranDavid GohDaniel H. SuHuaizhou WangVernon K. YongLeonard W. YipTuyet Bach TrinhManchima MakornwattanaThanh Thu NguyenEdgar U. LeuenbergerKi Ho ParkWidya Artini WiyogoRajesh SKumarCelso TelloYasuo KurimotoSuman S. ThapaKessara PathanapitoonJohn F. SalmonYong Ho SohnAntonio FeaMineo OzakiJimmy S.M. LaiVisanee TantiseviChaw Chaw KhaingTakanori MizoguchiSatoko NakanoChan Yun KimGuangxian TangSujie FanRenyi WuHailin MengThi Thuy Giang NguyenTien Dat TranMorio UenoJose Maria MartinezNorlina RamliYin Mon AungRigo Daniel ReyesStephen A. VernonSeng Kheong FangZhicheng XieXiao Yin ChenJia Nee FooA-Star, Genome Institute of SingaporeDuke-NUS Medical School SingaporeNational University of SingaporeVietnam National Institute of OphthalmologyBeijing Tongren HospitalKyoto Prefectural University of MedicineMedical Research Foundation, ChennaiKing Saud University Medical CollegeUniversity of FloridaAravind Medical Research FoundationChinese University of Hong KongTan Tock Seng HospitalUniversity of the RyukyusUniversidade Estadual de CampinasSchool of Medical Sciences - Universiti Sains MalaysiaInstituto de Glaucoma y CatarataMedical University of LublinMoorfields Eye Hospital NHS Foundation TrustUCL Institute of OphthalmologyUniversität HeidelbergHo Chi Minh City Oncology HospitalCOMSATS Institute of Information TechnologyAl-Shifa Trust Eye HospitalRadboud University Nijmegen Medical CentreNational University Health SystemKing Khaled Eye Specialist HospitalAll India Institute of Medical Sciences, New DelhiDa Nang Eye HospitalFlinders UniversityMahidol UniversityRajavithi HospitalRangsit UniversityUniversity of Medicine-MandalayKuala Lumpur HospitalVision Research Foundation IndiaChangi General HospitalFaculty of Medicine, Thammasat UniversityViet Tiep General HospitalAsian Eye InstituteUniversity of the East, PhilippinesSeoul National UniversityJakarta Eye CenterUniversitas IndonesiaNarayana Nethralaya Eye HospitalNew York Eye and Ear InfirmaryKobe City Medical Center General HospitalTilganga Institute of OphthalmologyChiang Mai UniversityUniversity of OxfordKonyang UniversityUniversità degli Studi di TorinoOzaki Eye HospitalUniversity of MiyazakiThe University of Hong KongChulalongkorn UniversityNo. 1 Defence Services General HospitalMizoguchi Eye ClinicOita UniversityYonsei UniversityShijiazhuang First Eye HospitalHandan Eye HospitalXiamen UniversityAnyang Eye HospitalPasig City General HospitalUniversity of MalayaPun Hlaing Silom HospitalShwe La Min HospitalAsian Hospital and Medical Center, MuntinlupaBinan Doctors HospitalNottingham University Hospitals NHS TrustBMI Park HospitalInternational Specialist Eye CentreAravind Eye Hospital2018-12-112019-03-142018-12-112019-03-142016-05-01Nature Genetics. Vol.48, No.5 (2016), 556-56215461718106140362-s2.0-84963502585https://repository.li.mahidol.ac.th/handle/123456789/43017© 2016 Nature America, Inc. Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10 -5), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10 -6), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10 -4), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10 -1), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10 -2). We also confirmed significant association at three previously described loci (P < 5 × 10 â'8 for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1038/ng.3540