Evaluation of ethyl: N -(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

Matthew D. StephensNisakorn YodsanitChristian MelanderNorth Carolina State UniversityMahidol University2018-12-112019-03-142018-12-112019-03-142016-01-01Organic and Biomolecular Chemistry. Vol.14, No.28 (2016), 6853-6856147705202-s2.0-84978785857https://repository.li.mahidol.ac.th/handle/20.500.14594/43198© 2016 The Royal Society of Chemistry. A small molecule library consisting of 45 compounds was synthesized based on the bacterial metabolite ethyl N-(2-phenethyl) carbamate. Screening of the compounds revealed a potent analogue capabale of inhibiting several strains of Methicillin Resistant S. aureus biofilms with low to moderate micromolar IC50values.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryEvaluation of ethyl: N -(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureusArticleSCOPUS10.1039/c6ob00706f