Y. MetugriachukF. MarottaK. PavasuthipaisitO. KuroiJ. TsuchiyaA. LorenzettiE. FesceE. MinelliTMC HospitalBiokenkyusho Research LaboratoryS. Giuseppe HospitalUniversita degli Studi di MilanoMahidol University2018-08-202018-08-202006-06-01Rejuvenation Research. Vol.9, No.2 (2006), 342-345154916842-s2.0-33744948334https://repository.li.mahidol.ac.th/handle/20.500.14594/23035Motility recording of small and large intestine was performed in old Wistar rats divided into three groups: (a) standard diet, (b) standard diet plus a symbiotic preparation, and (c) standard diet plus a heat-inactivated symbiotic preparation. SCM-III. significantly increased the myoelectric activity of small intestine and colon (p < 0.01 versus [a] and [c]) paralleling "young" values of 4-month-old rats and increased the spike burst frequency in the proximal-distal colon (p < 0.05). SCM-III significantly increased the frequency and duration of spike bursts in the jejunum, transverse-distal colon, and defecation frequency, while decreasing the intervals of migrating motor complex in the colon (p < 0.01) to "young" values with an increased mRNA expression of VIP (p < 0.05). Gut flora manipulation aimed to modulate myoelectric activity can tentatively help reversing age-related motility decay. © Mary Ann Liebert, Inc.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineConference PaperSCOPUS10.1089/rej.2006.9.342