α-Glucosidase inhibitory, aromatase inhibitory, and antiplasmodial activities of a biflavonoid gb1 from garcinia kola stem bark

Bassey S. AntiaAcharavadee PansanitOkon D. EkpaUdofot J. EkpeChulabhorn MahidolPrasat KittakoopChulabhorn Research InstituteUniversity of CalabarCenter for Environmental HealthThe Institute of Science and Technology for Research and Development, Mahidol University2018-09-242018-09-242010-02-25Planta Medica. Vol.76, No.3 (2010), 276-27714390221003209432-s2.0-77049113531https://repository.li.mahidol.ac.th/handle/20.500.14594/28781The biflavonoid, 3,4,4,5,5,7,7-heptahydroxy-3,8-biflavanone, known as GB1 (1), was isolated as a major constituent from Garcinia kola stem bark. GB1 (1) exhibited -glucosidase and aromatase inhibitory activities, as well as antiplasmodial activity, but was not toxic against cell lines tested. GB1 (1) may be a potential dietary supplement or phytomedicine for the prevention of breast cancer and type 2 diabetes mellitus. © Georg Thieme Verlag KG Stuttgart · New York.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and Pharmaceuticsα-Glucosidase inhibitory, aromatase inhibitory, and antiplasmodial activities of a biflavonoid gb1 from garcinia kola stem barkArticleSCOPUS10.1055/s-0029-1186081