Fatai A. FehintolaKimberly K. ScarsiQing MaSunil ParikhGene D. MorseBabafemi TaiwoIbrahim Tope AkinolaIsaac F. AdewoleNiklas LindegardhAphiradee PhakderajOladosu OjengbedeRobert L. MurphyOlusegun O. AkinyinkaFrancesca T. AweekaUniversity of IbadanNorthwestern University Feinberg School of MedicineUniversity at Buffalo, State University of New YorkUniversity of California, San FranciscoUniversity College Hospital, IbadanMahidol University2018-06-112018-06-112012-12-01AIDS Research and Treatment. Vol.2012, (2012)20901259209012402-s2.0-84873831726https://repository.li.mahidol.ac.th/handle/20.500.14594/14486Background. Nevirapine- (NVP-) based antiretroviral therapy (ART) and artesunate-amodiaquine are frequently coprescribed in areas of HIV and malaria endemicity. We explored the impact of this practice on artesunate and dihydroartemisinin pharmacokinetics. Methods. We conducted a parallel-group pharmacokinetic comparison between HIV-infected patients receiving NVP-based ART (n=10) and ART-naive controls (n=11). Artesunate-amodiaquine 200/600 mg was given daily for three days. Measurement of drug concentrations occurred between 0 and 96 hours after the final dose. Pharmacokinetic parameters were determined using noncompartmental analysis. Results. Comparing the NVP group to controls, clearance of artesunate was reduced 50% (1950 versus 2995 L/h; P=0.03), resulting in a 45% increase in the AUC(105 versus 69 ug hr/L; P=0.02). The half-life of dihydroartemisinin was shorter in the NVP group (1.6 versuss 3.2 h; P=0.004), but other dihydroartemisinin pharmacokinetic parameters were unchanged. A lower conversion of artesunate to dihydroartemisinin was observed in the NVP group (dihydroartemisinin: artesunate AUC=5.6 versuss 8.5 in NVP and control groups, respectively, P=0.008). Conclusion. Although NVP-containing ART impacted some pharmacokinetic parameters of artesunate and dihydroartemisinin, overall exposure was similar or better in the NVP group. © 2012 Fatai A. Fehintola et al.Mahidol UniversityMedicineArticleSCOPUS10.1155/2012/703604