Synthesis of 2-(2-arylethyl)imidazoles by direct alkylation of 1-(n,n-dimethylaminomethyl)2-lithiomethylimidazole

Bongkoch TarnchompooChachanat ThebtaranonthYodhathai ThebtaranonthMahidol University2018-06-142018-06-141990-01-01Tetrahedron Letters. Vol.31, No.40 (1990), 5779-5780004040392-s2.0-0025163548https://repository.li.mahidol.ac.th/handle/20.500.14594/15920Direct deprotonation of 1-(N,N-dimethylaminomethyl)2-methylimidazole 4 by n-butyllithium yields anion 5 which can readily undergo alkylation reactions. This finding provides immediate access to 2-(2-arylethyl)imidazoles, 1, which are clumsy to prepare by other methods. © 1990.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsSynthesis of 2-(2-arylethyl)imidazoles by direct alkylation of 1-(n,n-dimethylaminomethyl)2-lithiomethylimidazoleArticleSCOPUS10.1016/S0040-4039(00)97957-7