H. ByakwagaK. PetoumenosJ. AnanworanichF. ZhangM. A. BoydT. SirisanthanaP. C.K. LiC. LeeC. V. MeanV. SaphonnS. F.S. OmarS. PujariP. PhanuphakP. L. LimN. KumarasamyY. M.A. ChenT. P. MeratiS. SungkanuparphR. DitangcoS. OkaG. TauJ. ZhouM. G. LawS. EmeryUniversity of New South Wales (UNSW) AustraliaThe HIV Netherlands Australia Thailand Research CollaborationBeijing Ditan HospitalResearch Institute for Health SciencesQueen Elizabeth Hospital Hong KongHospital Sungai BulohNational Center for HIV/AIDSUniversity of MalayaInstitute of Infectious DiseasesTan Tock Seng HospitalYR Gaitonde Centre for AIDS Research and EducationNational Yang-Ming University TaiwanUniversitas UdayanaMahidol UniversityGokilaNational Center for Global Health and MedicinePort Moresby General Hospital2018-10-192018-10-192013-07-01Journal of the International Association of Providers of AIDS Care. Vol.12, No.4 (2013), 270-27723259582232595742-s2.0-84880437582https://repository.li.mahidol.ac.th/handle/20.500.14594/31904The majority of HIV-infected patients in developing countries commences combination antiretroviral therapy (cART) with advanced disease. We examined predictors of disease progression in patients initiating cART with CD4 count ≤200 cells/mm3 in the TREAT Asia HIV Observational Database. The main outcome measure was progression to either an AIDS-defining illness or death occurring 6 months after initiation of cART. We used survival analysis methods. A total of 1255 patients contributed 2696 person years of follow-up; 73 were diagnosed with AIDS and 9 died. The rate of progression to the combined end point was 3.0 per 100 person years. The factors significantly associated with a higher risk of disease progression were Indian ethnicity, infection through intravenous drug use, lower CD4 count, and hemoglobin ≤130 g/dL at 6 months. In conclusion, measurements of CD4 count and hemoglobin at month 6 may be useful for early identification of disease progression in resource-limited settings. © The Author(s) 2012.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1177/1545109712469684