Chariya BrockelmanSuthat FucharoenPrapon WilairatJamaree Bhisutthibhand2025-02-032025-02-03198820251988Thesis (M.Sc. (Microbiology))--Mahidol University, 1988https://repository.li.mahidol.ac.th/handle/20.500.14594/103276Microbiology (Mahidol University 1988)This study is aimed at investigating the effect of oxidative stress on the development of Plasmodium falciparum in ?-thalassemia erythrocytes in vitro. P. falciparum cultured in erythrocytes from normal (n = 16), ?-thalassemia 1 trait (n = 20), ?-thalassemia 2 trait (n = 10), Hb CS trait (n = 8) was subjected to H(,2)O(,2), generated from the reaction of glucose-glucose oxidase. Results from experiments revealed that malaria parasite in ?-thalassemia 2 trait and Hb CS trait erythrocytes were more susceptible to H(,2)O(,2) than that in ?-thalassemia 1 trait which was not significantly different from normal erythrocyte. The reduction of parasite survival was more pronounced when the thalassemia sera were used.ix, 103 leaves : ill.application/pdfengผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้าErythrocytesHydrogen PeroxideOxidoreductasesPlasmodium falciparum -- Growth & developmentThalassemiaMaster ThesisMahidol University