Jurairat NunthanidSatit PuttipipatkhachornKeiji YamamotoGarnet E. PeckMahidol UniversityChiba UniversityPurdue University2018-09-072018-09-072001-03-22Drug Development and Industrial Pharmacy. Vol.27, No.2 (2001), 143-157036390452-s2.0-0035094735https://repository.li.mahidol.ac.th/handle/20.500.14594/26515Chitosan films, varying in molecular weight and degree of deacetylation, were prepared by a casting technique using acetic acid as a dissolving vehicle. The physicochemical properties of the films were characterized. Both molecular weight and degree of deacetylation affected the film properties. Powder X-ray diffraction patterns and differential scanning calorimetry thermograms of all chitosan films indicated their amorphous state to partially crystalline state with thermal degradation temperature lower than 280-300°C. The increase in molecular weight of chitosan would increase the tensile strength and elongation as well as moisture absorption of the films, whereas the increase in degree of deacetylation of chitosan would either increase or decrease the tensile strength of the films depending on its molecular weight. Moreover, the higher the degree of deacetylation of chitosan the more brittle and the less moisture absorption the films became. All chitosan films were soluble in HCl-KCl buffer (pH 1.2), normal saline, and distilled water. They swelled in phosphate buffer (pH 7.4), and cross-linking between chitosan and phosphate anions might occur. Finally, transmission infrared and13C-NMR spectra supported that chitosan films prepared by using acetic acid as a dissolving were chitosonium acetate films.Mahidol UniversityChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1081/DDC-100000481