Pat MahachoklertwattanaArporn SriphrapradangSarayut SupapannachartAroonwan PongsuwanLulin ChoubtumRajata RajatanavinMahidol University2018-09-072018-09-071999-12-01Journal of the Medical Association of Thailand. Vol.82, No.SUPPL. (1999)012522082-s2.0-28144446512https://repository.li.mahidol.ac.th/handle/20.500.14594/25540Objectives: To construct a normative data for serum thyroxine (T4), free T4(FT4), triiodothyronine (T3) and thyrotropin (TSH) in Thai neonates. Study design: A cross-sectional study of 275 healthy full-term neonates was conducted. Blood samples were obtained from umbilical cords of the neonates and from heel pads of infants aged 1-30 days. Hormone measurements included serum T4, FT4, T3and TSH. Results: Mean serum T4and FT4levels rapidly increased after delivery to the maximum level at 1-3 days of age. Thereafter, they declined to a steady state level within 2-4 weeks. Mean serum T3level was very low at birth. The concentration increased 3-5 times and reached a steady state levels within 1 week. In contrast, mean serum TSH declined from birth and the level at 1-3 days of age was slightly less than that of the cord blood. It changed little after 3 days of age. Previous studies have shown a transient TSH surge in the first 24-48 hour of life. TSH surge was not apparent in our study because samples were not obtained from infants <24 hours old. Therefore, if TSH is measured for screening of congenital hypothyroidism, samples should be obtained from umbilical cord or infants aged >48 hours. Conclusions: This study provides the normative data for thyroid function tests in Thai full-term neonates. These data are useful for detection and verification of hypothyroidism in a screening program for congenital hypothyroidism.Mahidol UniversityMedicineArticleSCOPUS