Walter P. WeberMartin HaugChristian KurzederVesna Bjelic-RadisicRupert KollerRoland ReitsamerFlorian FitzalJorge BiazusFabricio BrenelliCicero UrbanRégis Resende PaulinelliJens Uwe BlohmerJörg HeilJürgen HoffmannZoltan MatraiGiuseppe CatanutoViviana GalimbertiOreste GentiliniMitchel BarryTal HadarTanir M. AllweisOded OlshaMaria João CardosoPedro F. GouveiaIsabel T. RubioJana de BonifaceTor SvensjöSusanne BucherPeter DubskyJian FarhadiMathias K. FehrIlario FulcoUrsula Ganz-BlättlerAndreas GünthertYves HarderNik HauserElisabeth A. KapposMichael KnauerJulia LandinRobert MecheraFrancesco MeaniGiacomo MontagnaMathilde RitterRamon SaccilottoFabienne D. SchwabDaniel SteffensChristoph TauschJasmin ZeindlerSavas D. SoysalVisnu LohsiriwatTibor KovacsAnne TansleyLynda WyldLaszlo RomicsMahmoud El-TamerAndrea L. PusicVirgilio SacchiniMichael GnantNew Victoria Hospital, GlasgowChampalimaud FoundationUniversidade PositivoAzienda Ospedaliera CannizzaroIRCCS San Raffaele Scientific InstituteKlinik St. AnnaUniklinik DüsseldorfEnte Ospedaliero CantonaleUniversidad de NavarraKaplan Medical Center IsraelKantonsspital LuzernOrszágos Onkológiai Intézet BudapestIstituto Europeo di OncologiaUniversidade Estadual de CampinasUniversitätsspital BaselUniversität St. GallenCharité – Universitätsmedizin BerlinKristianstad Central HospitalUniversitat BaselCentre Hospitalier Universitaire VaudoisUniversität Witten/HerdeckeMater Misericordiae University HospitalBrigham and Women's HospitalHospital de Clinicas de Porto AlegreKarolinska InstitutetMedizinische Universitat WienKlinik HirslandenFaculty of Medicine, Siriraj Hospital, Mahidol UniversityMemorial Sloan-Kettering Cancer CenterRoyal Liverpool and Broadgreen University Hospitals NHS TrustHebrew University of JerusalemMedizinische Universität GrazGuy's and St Thomas' NHS Foundation TrustUniversitat SalzburgUniversity of SheffieldCapio S:t Görans SjukhusWiener KrakenanstaltenverbundBreast Center ZürichBreast Center St. GallenUniversity of HeidelbergAraújo Jorge Hospital2019-08-232019-08-232018-12-01Breast Cancer Research and Treatment. Vol.172, No.3 (2018), 523-53715737217016768062-s2.0-85053429342https://repository.li.mahidol.ac.th/handle/123456789/44993© 2018, The Author(s). Purpose: Indications for nipple-sparing mastectomy (NSM) have broadened to include the risk reducing setting and locally advanced tumors, which resulted in a dramatic increase in the use of NSM. The Oncoplastic Breast Consortium consensus conference on NSM and immediate reconstruction was held to address a variety of questions in clinical practice and research based on published evidence and expert panel opinion. Methods: The panel consisted of 44 breast surgeons from 14 countries across four continents with a background in gynecology, general or reconstructive surgery and a practice dedicated to breast cancer, as well as a patient advocate. Panelists presented evidence summaries relating to each topic for debate during the in-person consensus conference. The iterative process in question development, voting, and wording of the recommendations followed the modified Delphi methodology. Results: Consensus recommendations were reached in 35, majority recommendations in 24, and no recommendations in the remaining 12 questions. The panel acknowledged the need for standardization of various aspects of NSM and immediate reconstruction. It endorsed several oncological contraindications to the preservation of the skin and nipple. Furthermore, it recommended inclusion of patients in prospective registries and routine assessment of patient-reported outcomes. Considerable heterogeneity in breast reconstruction practice became obvious during the conference. Conclusions: In case of conflicting or missing evidence to guide treatment, the consensus conference revealed substantial disagreement in expert panel opinion, which, among others, supports the need for a randomized trial to evaluate the safest and most efficacious reconstruction techniques.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineReviewSCOPUS10.1007/s10549-018-4937-1