Timmy RichardoPongphol PrattapongChawalit NgernsombatNurulfitri WisetyaningsihHisashi IizasaHironori YoshiyamaTavan JanvilisriShimane UniversityMedizinische Hochschule Hannover (MHH)Mahidol UniversityIndonesia International Institute for Life Sciences2020-11-182020-11-182020-09-01Cancers. Vol.12, No.9 (2020), 1-23207266942-s2.0-85091988116https://repository.li.mahidol.ac.th/handle/20.500.14594/59880© MDPI AG. All rights reserved. Nasopharyngeal carcinoma (NPC) is one of the most common tumors occurring in China and Southeast Asia. Etiology of NPC seems to be complex and involves many determinants, one of which is Epstein-Barr virus (EBV) infection. Although evidence demonstrates that EBV infection plays a key role in NPC carcinogenesis, the exact relationship between EBV and dysregulation of signaling pathways in NPC needs to be clarified. This review focuses on the interplay between EBV and NPC cells and the corresponding signaling pathways, which are modulated by EBV oncoproteins and non-coding RNAs. These altered signaling pathways could be critical for the initiation and progression of NPC.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineReviewSCOPUS10.3390/cancers12092441