Sudarat HomhualNuntavan BunyapraphatsaraTamara KondratyukAngkana HerunsaleeWongsatit ChaukulJohn M. PezzutoHarry H S FongHong Jie ZhangMahidol UniversityPurdue UniversityThailand Ministry of Public HealthUniversity of Illinois at Chicago2018-08-202018-08-202006-03-01Journal of Natural Products. Vol.69, No.3 (2006), 421-424016338642-s2.0-33646006363https://repository.li.mahidol.ac.th/handle/20.500.14594/22913Three new dammarane triterpenes, bruguierins A-C (1-3), were isolated from a petroleum ether extract of the flowers of Bruguiera gymnorrhiza. Their structures were determined on the basis of physical and spectroscopic data interpretation. With stably transfected HepG2 cells, the three isolates activated antioxidant response element (ARE luciferase activation) with EC50 values of 7.8, 9.4, and 15.7 μM, respectively. Bruguierin A (1) also inhibited phorbol ester-induced NFκB (nuclear factor-κB) luciferase activation with an IC50 value of 1.4 μM and selectively inhibited cyclooxygenase-2 (COX-2) activity with an IC50 value of 0.37 μM. Compounds 2 and 3 were not active in these bioassays. © 2006 American Chemical Society and American Society of Pharmacognosy.Mahidol UniversityAgricultural and Biological SciencesChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np058112x