C. PromchainantMahidol University2018-04-192018-04-191975-01-01Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Vol.28, No.1 (1975), 107-112002751072-s2.0-0016640505https://repository.li.mahidol.ac.th/handle/20.500.14594/10743Human leukocytes treated with bleomycin (BLM) for clinical use, at concentrations of 0.1, 0.5, 1.0, 10 and 50 μg/ml were studied. Both chromosome- and chromatid-type aberrations were observed. The groups of larger chromosomes were more affected at every concentration. At dosages from 0.1 to 10 μ/ml no significant difference of effects on chromosomes was observed. However, a dose-difference of about 500 times showed significant differences in effect both on the degree of chromosomal aberration and on mitotic indices. © 1975.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyEnvironmental ScienceMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/0027-5107(75)90320-6