Veena S. NukoolkarnSuwipa Saen-oonThanyada RungrotmongkolSupot HannongbuaKornkanok IngkaninanKhanit SuwanboriruxMahidol UniversityNaresuan UniversityCenter for Bioactive Natural Products from Marine Organisms and Endophytic Fungi (BNPME)Chulalongkorn University2018-07-122018-07-122008-07-01Bioorganic and Medicinal Chemistry. Vol.16, No.13 (2008), 6560-6567096808962-s2.0-44749084695https://repository.li.mahidol.ac.th/handle/20.500.14594/18901Two pyridoacridine alkaloids, including a known petrosamine and a new 2-bromoamphimedine were isolated from a Thai marine sponge Petrosia n. sp. The alkaloids were characterized on the basis of 1D and 2D NMR, MS, and IR spectroscopy. Only petrosamine showed strong acetylcholinesterase inhibitory activity approximately six times higher than that of the reference galanthamine. A computational docking study of petrosamine with the enzyme from the electric eel Torpedo californica (TcAChE) showed the major contribution to the petrosamine-TcAChE interaction to be arising from the quaternary ammonium group of petrosamine. © 2008 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.bmc.2008.05.027