I. Ming TangNateetip KrishnamraNarattaphol CharoenphandhuRassmidara HoonsawatWeeraphat Pon-OnCommission of Higher EducationMahidol University2018-06-112018-06-112012-01-26Nanoscale Research Letters. Vol.7, (2012), 1-101556276X193175732-s2.0-84856077325https://repository.li.mahidol.ac.th/handle/20.500.14594/14382Magnetic nanoparticle composite with a cobalt ferrite (CoFe 2 O 4 , (CF)) core and an apatite (Ap) coating was synthesized using a biomineralization process in which a modified simulated body fluid (1.5SBF) solution is the source of the calcium phosphate for the apatite formation. The core-shell structure formed after the citric acid- stabilized cobalt ferrite (CFCA) particles were incubated in the 1.5 SBF solution for 1 week. The mean particle size of CFCA-Ap is about 750 nm. A saturation magnetization of 15.56 emug -1 and a coercivity of 1808.5 Oe were observed for the CFCA-Ap obtained. Bovine serum albumin (BSA) was used as the model protein to study the adsorption and release of the proteins by the CFCA-Ap particles. The protein adsorption by the CFCA-Ap particles followed a more typical Freundlich than Langmuir adsorption isotherm. The BSA release as a function of time became less rapid as the CFCA-Ap particles were immersed in higher pH solution, thus indicating that the BSA release is dependent on the local pH. © 2010 Tang et al.Mahidol UniversityMaterials SciencePhysics and AstronomyArticleSCOPUS10.1186/1556-276X-7-19