Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm)

Chakkaphan RuncharoenKoya FukunagaInsee SensornNareenart IemwimangsaSommon KlumsathianHang TongNam Sy VoLy LeTin Maung HlaingMyo ThantShamsul Mohd ZainZahurin MohamedYuh Fen PungFrancis CapuleJose NevadoCatherine Lynn SilaoZeina N. Al-MahayriBassam R. AliRika YuliwulandariKinasih PrayuniHilyatuz ZahrohDzul Azri Mohamed NoorPhonepadith XangsayarathDalouny XayavongSengchanh KounnavongSomphou SayasoneZoe KordouIoannis LiopetasAthina TsikrikaEvangelia Eirini TsermpiniMaria KorominaChristina MitropoulouGeorge P. PatrinosAumpika KesornsitAngkana CharoenyingwattanaSukanya WattanapokayakitSurakameth MahasirimongkolTaisei MushirodaWasun ChantratitaFaculty of Medicine, YARSI UniversityYARSI UniversitySchool of Pharmaceutical Sciences, Universiti Sains MalaysiaInternational University,Vietnam National University Ho Chi Minh CityThe University of Nottingham Malaysia CampusUniversity of the Philippines ManilaUniversity of the Philippines College of MedicineCollege of Medicine and Health Sciences United Arab Emirates UniversitySchool of Health SciencesUniversiti MalayaRikenFaculty of Medicine Ramathibodi Hospital, Mahidol UniversityThailand Ministry of Public HealthMahidol UniversityDefence Services Medical Research CentreDefence Services Medical AcademyVingroup Big Data InstituteLao Tropical and Public Health InstituteThe Golden Helix FoundationNational Center for Laboratory and Epidemiology2022-08-042022-08-042021-12-01Human Genome Variation. Vol.8, No.1 (2021)2054345X2-s2.0-85100592571https://repository.li.mahidol.ac.th/handle/20.500.14594/75952Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing publicly available data. A panel of 100 pharmacogenes among Southeast Asian (SEA) populations was resequenced using the NGS platform under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Here, we present the frequencies of pharmacogenomic variants and the comparison of these pharmacogenomic variants among different SEA populations and other populations used as controls. We investigated the different types of pharmacogenomic variants, especially those that may have a functional impact. Our results provide substantial genetic variations at 100 pharmacogenomic loci among SEA populations that may contribute to interpopulation variability in drug response phenotypes. Correspondingly, this study provides basic information for further pharmacogenomic investigations in SEA populations.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyPrevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm)ArticleSCOPUS10.1038/s41439-021-00135-z