Saowaluk SawangdeeYuvadee WongkrajangSuchitra ThongpraditchotePenchom PeungvichaBoonthium KongsaktrakoonChuthamanee Suthisisangเสาวลักษณ์ สว่างดียุวดี วงษ์กระจ่างสุจิตรา ทองประดิษฐ์โชติเพ็ญโฉม พึ่งวิชาบุญเทียม คงศักดิ์ตระกูลจุฑามณี สุทธิสีสังข์Mahdiol University. Faculty of Pharmacy. Department of PhysiologyMahdiol University. Faculty of Pharmacy. Department of Pharmacology2015-03-282021-06-022015-03-282021-06-0220152012Journal of Asian Association of Schools of Pharmacy. 2012;Vol.1, No.4 (2012), 226-34.https://repository.li.mahidol.ac.th/handle/20.500.14594/62559Phenylpropanolamine (PPA) is a sympathomimetic drug that exerts its effect mainly through the alphaadrenergic receptor. A pharmacoepidemiological study reported by the hemorrhagic stroke project in the year 2000 suggested an association between high dose PPA and hemorrhagic stroke. However, the hemodynamic effect of PPA might be altered in the presence of chlorpheniramine (CPM) as used in over-the-counter cold remedy (PPA, 0.3 mg/kg plus CPM, 0.04 mg/kg). It was found that PPA (5-30 times that used in humans) dose-dependently increased in blood pressure in rats and this effect was antagonized by CPM in male rats and non-proestrous female rats but not in proestrous female rats. The hypertensive effect of PPA could not be antagonized by loratadine, a highly specific H1 blocker.804 KBapplication/pdfengMahdiol UniversityPhenylpropanolamineChlorpheniramineBlood PressureSympathomimetic drugHemorrhagic strokeResearch ArticleAsian Association of Schools of Pharmacy