Lina F. ChalakKim Anh NguyenChatchay PrempunpongRoy HeyneSudhin ThayyilSeetha ShankaranAbbot R. LaptookNancy RollinsAthina PappasLouise KoclasBirju ShahPaolo MontaldoBenyachalee TechasaensiriPablo J. SánchezGuilherme Sant’AnnaOhio State University College of MedicineUT Southwestern Medical CenterImperial College LondonMahidol UniversityBrown UniversityWayne State UniversityCentre universitaire de santé McGill2019-08-232019-08-232018-12-01Pediatric Research. Vol.84, No.6 (2018), 861-86815300447003139982-s2.0-85053845544https://repository.li.mahidol.ac.th/handle/20.500.14594/46170© 2018, International Pediatric Research Foundation, Inc. Background: Studies of early childhood outcomes of mild hypoxic-ischemic encephalopathy (HIE) identified in the first 6 h of life are lacking. Objective: To evaluate neurodevelopmental outcomes at 18–22 months of PRIME study. Study design: Multicenter, prospective study of mild HIE defined as ≥1 abnormality using the modified Sarnat within 6 h of birth and not meeting cooling criteria. Primary outcome was disability with mild: Bayley III cognitive 70–84 or ≥85 and either Gross Motor Function Classification System (GMFCS) 1 or 2, seizures, or hearing deficit; moderate: cognitive 70–84 and either GMFCS 2, seizures, or hearing deficit; severe: cognitive <70, GMFCS 3–5. Results: Of the 63 infants enrolled, 51 (81%) were evaluated at 19 ± 2 months and 43 (68%) completed Bayley III. Of the 43 infants, 7 (16%) were diagnosed with disability, including 1 cerebral palsy and 2 autism. Bayley scores < 85 in either cognition, motor, or language were detected in 17 (40%): 14 (32%) language, 7 (16%) cognitive, and 6 (14%) motor domain. Infants with disability had more abnormalities on discharge examination and brain MRI, with longer hospital stay (p < 0.001). Conclusions: In this contemporary untreated cohort of mild HIE, disability occurred in 16% of infants at 18–22 months.Mahidol UniversityMedicineArticleSCOPUS10.1038/s41390-018-0174-x