Sa-nguanpong P.Wetprasit P.Inchan A.Chaichana C.Kaewkong W.Charoenphon N.Adthapanyawanich K.Tantanarat K.Tochampa W.Ruttarattanamongkol K.Bualeong T.Mahidol University2025-04-022025-04-022025-04-01Journal of Functional Foods Vol.127 (2025)17564646https://repository.li.mahidol.ac.th/handle/20.500.14594/108621This study evaluates the antihypertensive effects of Sacha Inchi meal protein hydrolysate (SIPH) in L-NAME-induced hypertensive rats. Male Sprague Dawley rats treated with L-NAME (40 mg/kg) received SIPH (100, 300, or 500 mg/kg), captopril (5 mg/kg), or a combination of captopril (2.5 mg/kg) and SIPH (500 mg/kg) for 5 weeks. Blood pressure was monitored weekly and verified via carotid artery cannulation. SIPH at 500 mg/kg, incombination with captopril, significantly reduced blood pressure, upregulated eNOS expression, alleviated renal and liver injury, enhanced sperm viability, and downregulated VCAM-1 expression. In HepG2 and 3 T3-L1 cells, SIPH mitigated oxidative stress, hepatic steatosis, and lipid accumulation. Together, these in vitro and in vivo findings suggest that SIPH could serve as a promising nutraceutical candidate for antihypertensive functional foods.NursingAgricultural and Biological SciencesMedicineArticleSCOPUS10.1016/j.jff.2025.1067722-s2.0-105000797192