Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania.

Färnert, AnnaUrsing, JohanTolfvenstam, ThomasRono, JoseaKarlsson, LillemorSparrelid, EldaLindegårdh, NiklasMahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit.2014-06-302016-09-212014-06-302016-09-2120122014-06-252012-05-25Färnert A, Ursing J, Tolfvenstam T, Rono J, Karlsson L, Sparrelid E, et al. Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania. Malar J. 2012 May 25;11:176.1475-2875 (electronic)1475-2875 (Linking)https://repository.li.mahidol.ac.th/handle/20.500.14594/666Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa. Genotyping confirmed recrudescence and suggested reduced sensitivity. Potential sub-optimal effect of artemether-lumefantrine highlights the need to follow non-immune individuals the weeks after treatment.engMahidol UniversityArtemisninLumefantrineMalarianon-immuneP. falciparumOpen Access articleArtemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania.BioMed Central10.1186/1475-2875-11-176.