Yaowaree KittikalayawongMonnipha Sila-asnaAhnond BunyaratvejMahidol UniversityThe Institute of Science and Technology for Research and Development, Mahidol UniversityChulalongkorn UniversityNational Research Council of Thailand2018-06-212018-06-212005-09-01Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.5 (2005), 1298-1303012515622-s2.0-30344444000https://repository.li.mahidol.ac.th/handle/20.500.14594/16847Upon erythroid cell maturation in vivo, β-thalassemic erythroid cells accumulate unmatched unstable α-globin chains that are believed to be a causal factor in such cell destruction. This study showed that β-thalassemia/Hb E erythroid precursor cells from peripheral blood had accelerated maturation, and could mature to the terminal erythroid stage. During the early period of cell culture, erythroid precursor cells derived from subjects with the more severe form of β-thalassemia/Hb E had higher rate of erythroid maturation. In addition, peripheral blood mononuclear cells from β-thalassemia/Hb E subjects had higher erythroid proliferative potential than cells derived from normal controls. Erythroid proportion in the more severe β-thalassemia/Hb E cases was less than that of the milder cases. Premature apoptosis was not observed during the 15 days of erythroid cell culture from both β-thalassemia/Hb E and normal subjects.Mahidol UniversityMedicineArticleSCOPUS